Publications & Data
2025
Garborg CS, Ghitti B, Zhang Q, Riccotta J, Frank N, Mueller S, Greenawalt D, Turner K, Kedarasetti R, Mostafa M, Lee H, Costanzo F, Drew PJ. Gut-Brain Hydraulics: Brain motion and CSF circulation is driven by mechanical coupling with the abdomen. bioRxiv. doi: 10.1101/2025.01.30.635779. [link] [data] [code]
Turner K, Brockway D, Hossain MS, Griffith K, Greenawalt D, Zhang Q, Gheres K, Crowley N, Drew PJ (2025) Type-I nNOS neurons orchestrate cortical neural activity and vasomotion. bioRxiv doi:10.1101/2025.01.21.634042 [link]
2024
Bennett HC, Zhang Q, Wu YT, Manjila SB, Chon U, Shin D, Vanselow DJ, Pi HJ, Drew PJ, Kim Y(2024) Aging drives cerebrovascular network remodeling and functional changes in the mouse brain. Nat Commun. 2024 Jul 30;15(1):6398. doi: 10.1038/s41467-024-50559-8 [link]
Chen H, Mirg S, Gaddale P, Agrawal S, Li M, Nguyen V, Xu T, Li Q, Liu J, Tu W, Liu X, Drew PJ, Zhang N, Gluckman BJ, Kothapalli SR (2024) Multiparametric Brain Hemodynamics Imaging Using a Combined Ultrafast Ultrasound and Photoacoustic System. Adv Sci (Weinh). 2024 Aug;11(31):e2401467. doi: 10.1002/advs.202401467 [link]
2023
Brockway DF, Griffith KR, Aloimonos CM, Clarity TT, Moyer JB, Smith GC, Dao NC, Hossain MS, Drew PJ, Gordon JA, Kupferschmidt DA, Crowley NA (2023) Somatostatin peptide signaling dampens cortical circuits and promotes exploratory behavior. Cell Reports 42. doi:10.1016/j.celrep.2023.112976 [link]
Gheres KW, Unsal HS, Han X, Zhang Q, Turner KL, Zhang N, Drew PJ (2023) Arousal state transitions occlude sensory-evoked neurovascular coupling in neonatal mice. Communications Biology, 20230218 [link][data][code]
Vo TT, Im GH, Han K, Suh M, Drew PJ, Kim SG (2023) Parvalbumin interneuron activity drives fast inhibition-induced vasoconstriction followed by slow substance P-mediated vasodilation, PNAS doi: 10.1073/pnas.2220777120 [link]
Turner KL, Gheres KW, Drew PJ, (2023) Relating pupil diameter and blinking to cortical activity and hemodynamics across arousal states, Journal of Neuroscience, 43, 949-964 doi:10.1523/JNEUROSCI.1244-22.2022 pdf [Data] [Code]
Zhang Q, Cramer SR, Turner KL, Neuberger T, Drew PJ, Zhang N (2023) High-frequency neuronal signal better explains multi-phase BOLD response. Neuroimage 268:119887.
doi:10.1016/j.neuroimage.2023.119887 pdf
Zhang Q, Haselden WD, Charpak S, Drew PJ (2023) Could respiration-driven blood oxygen changes modulate neural activity? Pflugers Arch 475:37-48. doi:10.1007/s00424-022-02721-8 pdf
2022
Drew PJ (2022), Drew PJ (2022) Neurovascular coupling: motive unknown. Trends Neurosci 45:809-819. doi:10.1016/j.tins.2022.08.004 pdf
Mirg S, Turner KL, Chen H, Drew PJ, Kothapalli SR. Photoacoustic Imaging for Microcirculation, Microcirculation. 2022 Jul 6:e12776. doi: 10.1111/micc.12776 (Review) pdf
Haselden WD, Drew PJ, Church EW (2022) Lessons for the pathogenesis of vasospasm from a patient with sickle cell disease, moyamoya disease, subarachnoid hemorrhage, and 1 month of persistent vasospasm: illustrative case. Journal of Neurosurgery: Case Lessons 4. doi:10.3171/case2290
Wu Y-T, Bennett HC, Chon U, Vanselow DJ, Zhang Q, Muñoz-Castañeda R, Cheng KC, Osten P, Drew PJ, Kim Y (2022) Quantitative relationship between cerebrovascular network and neuronal cell types in mice. Cell Reports 39. doi:10.1016/j.celrep.2022.110978 Link
Kedarasetti RK, Drew PJ, Costanzo F, (2022) Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model, Fluids and Barries of the CNS, 19:34 doi.org/10.1186/s12987-022-00326-y Link
Mirg S, Chen H, Turner KL, Gheres KW, Liu J, Gluckman BJ, Drew PJ, Kothapalli SR, (2022) Awake mouse brain photoacoustic and optical imaging through a transparent ultrasound cranial window, Opt Lett. Mar 1;47(5):1121-1124. doi: 10.1364/OL.450648 Link
Zhang Q, Cramer SR, Ma Z, Turner KL, Gheres KW, Liu Y, Drew PJ, Zhang N, (2022) Brain-wide ongoing activity is responsible for significant cross-trial BOLD variability, Cerebral Cortex doi.org/10.1093/cercor/bhac016 Link
Zhang Q, Turner KL†, Gheres KW†, Hossain MS†, Drew PJ, Behavioral and physiological monitoring for awake neurovascular coupling experiments: A how-to guide, Neurophotonics, 2022 (Invited Review) doi:10.1117/1.NPh.9.2.021905 Link
2021
Zhang Q, Gheres KW, Drew PJ, Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex PloS Biology, 2021 doi.org/10.1101/2020.09.18.303164 Link [Data] [Code]
Aydin AK, Haselden WD, Dang J, Drew PJ, Charpak S, Boido D, Iliski, a software for robust calculation of transfer functions, PLoS Computational Biology, 2021 Jun 14;17(6):e1008614 Link
Das A, Murphy K, Drew PJ. Rude mechanicals in brain haemodynamics: non-neural actors that influence blood flow. Philos Trans R Soc Lond B Biol Sci. 2021; 376(1815):20190635 doi: 10.1098/rstb.2019.0635. Link
2020
Turner KL, Gheres KW, Proctor EA, Drew PJ, Neurovascular coupling and bilateral connectivity during NREM and REM sleep, eLife 2020, 9:e62071 doi: 10.7554/eLife.62071 Link [Data] [Code]
Echagarruga C, Gheres KW, Norwood JN, Drew PJ, nNOS-expressing interneurons control basal and behaviorally-evoked arterial dilation in somatosensory cortex of mice, eLife 2020, 9:e60533 doi: 10.7554/eLife.60533 Link [Data & Code]
Kedarasetti R, Turner KL Jr., Echagarruga C, Gluckman BJ, Drew PJ, Costanzo F, Functional hyperemia drives fluid exchange in the paravascular space, Fluids and Barriers of the CNS 2020, Link [Code]
Drew PJ, Mateo C, Turner KL, Yu X, Kleinfeld D. Ultra-slow Oscillations in fMRI and Resting-State Connectivity: Neuronal and Vascular Contributions and Technical Confounds. Neuron 2020, 107(5):782-804. doi: 10.1016/j.neuron.2020.07.020. [pdf] [Code] [data]
Haselden WD, Kedarasetti PR, Drew PJ, Spatial and temporal patterns of nitric oxide diffusion and degradation drive emergent cerebrovascular dynamics, PLoS Computational Biology 2020, doi.org/10.1371/journal.pcbi.1008069 Link [Code]
Kedarasetti R, Drew PJ, Costanzo F, Arterial pulsations drive oscillatory flow of CSF but not directional pumping, Scientific Reports 2020, 10(1). doi.org/10.1038/s41598-020-66887-w Link
Aydin AK, Haselden WD, Houssen YG, Pouzat C, Rungta RL, Demené C, Tanter M, Drew PJ, Charpak S, Boido D, Transfer functions linking neural calcium to single voxel fUS signal, Nature Communications 2020, doi.org/10.1038/s41467-020-16774-9 Link
2019
Zhang Q, Roche M, Gheres KW, Chaigneau E, Kedarasetti R, Haselden WD, Charpak S, Drew PJ, Cerebral oxygenation during behavior is modulated by respiration, Nature Communications 2019, 10:5515 Link [Data and Code]
Norwood JN, Zhang Q, Card D, Craine A, Ryan TM, Drew PJ, Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate, eLife 2019, doi: 10.7554/eLife.44278 Link
Drew PJ, Vascular and neural basis of the BOLD signal. Current Opinion in Neurobiology 2019, 58:61-69. doi:10.1016/j.conb.2019.06.004
Drew-2019.pdf
Drew PJ, Winder AT, Zhang Q, Twitches, blinks, and fidgets: Important generators of ongoing neural activity, The Neuroscientist, 2019 doi: 10.1177/107385841880542 Drew-2018.pdf
2018
Adams MD*, Winder AT*, Blinder P, Drew PJ, The pial vasculature of the mouse develops according to a sensory-independent program, Scientific Reports, 8:9860, 2018
doi:10.1038/s41598-018-27910-3 Adams_2018.pdf [Data and Code]
2017
Winder AT, Echagarruga CE, Zhang Q, Drew PJ, Weak correlations between hemodynamic signals and ongoing neural activity during the resting state, Nature Neuroscience, 20(12):1761-1769, 2017 doi:10.1038/s41593-017-0007-y
Winder_NN_2017.pdf [Data & Code]
Gao Y-R, Ma Y, Zhang Q, Winder AT, Liang Z, Antinoi L, Drew PJ, Zhang N, Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal NeuroImage 153:382-398, 2017 doi: 10.1016/j.neuroimage.2016.11.069
Awake_NVC_review.pdf
2016
Gao Y-R, Drew PJ, Effects of voluntary locomotion and CGRP on the dynamics of single dural vessels in awake mice, Journal of Neuroscience, 36:2503–2516, 2016
doi :10.1523/JNEUROSCI.3665-15.201 Gao_JNeurosci_2016.pdf
2015
Huo BX, Green SE, Drew PJ, Venous cerebral blood volume increase during voluntary locomotion reflects cardiovascular changes, NeuroImage, 118:301-312, 2015
doi 10.1016/j.neuroimage.2015.06.011
Huo_NeuroImage_2015b.pdf
Shirey M, Smith JB, Greene SE, Huo BX, Drew PJ, Brief Anesthesia, but not Voluntary Locomotion, Significantly Alters Cortical Temperature, Journal of Neurophysiology ,114: 309–322 Shirey_Journal_of_Neurophysiology_2015.pdf
Gao YR, Greene SE, Drew PJ, Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response, NeuroImage, 115:162-176, 2015
Gao_NeuroImage_2015.pdf
Huo BX, Gao YR, Drew PJ, Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion, NeuroImage,15;105:369-79, 2015, Huo_NeuroImage_2015.pdf
2014
Letourneur A, Chen V, Waterman G, Drew PJ, A method for longitudinal, transcranial imaging of blood flow and remodeling of the cerebral vasculature in postnatal mice, Physiological Reports, 2(12). pii: e12238. 2014,
Letourneur_Physiological Reports_2014.pdf
Huo BX, Smith JB, Drew PJ, Neurovascular coupling and decoupling in the cortex during voluntary locomotion, Journal of Neuroscience, 34(33):10975–10981 Journal of Neuroscience 2014 Huo.pdf
Gao YR, Drew PJ, Determination of vessel cross-sectional area by thresholding in Radon space, Journal of Cerebral Blood Flow Metabolism 34(7):1180-7, 2014
J Cereb Blood Flow Metab 2014 Gao.pdf
pre-2014
Shih AY, Mateo C, Drew PJ, Tsai PS, Kleinfeld D. A polished and reinforced thinned-skull window for long-term imaging of the mouse brain. Journal of Visualized Experiments 7;(61), 2012 J Vis Exp 2012 Shih.pdf
Shih AY, Driscoll JD, Drew PJ, Nishimura N, Schaffer CB, Kleinfeld D. Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain. Journal of Cerebral Blood Flow Metabolism 2012 J Cereb Blood Flow Metab 2012 Shih.pdf
Drew PJ, Shih AY, Kleinfeld D, Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity, Proceedings of the National Academy of Sciences, 108(20):8473-8478, 2011 Proceedings of the National Academy of Sciences 2011 Drew.pdf
Drew PJ, Shih AY, Driscoll JD, Knutsen PM, Blinder P, Davalos D, Akassoglou K, Tsai PS, Kleinfeld D, Chronic optical access through a polished and reinforced thinned skull, Nature Methods 7:981-984, 2010.Nat Meth 2010 Drew.pdf
Drew PJ, Blinder P, Cauwenberghs G, Shih AY, Kleinfeld D, Rapid determination of particle velocity from space-time line-scan data using the Radon transform, Journal of Computational Neuroscience, 29(1-2):5-11 J Comput Neurosci 2010 Drew.pdf
Tsai PS, Kaufhold J, Blinder P, Friedman B, Drew PJ, Karten HJ, Lyden PD, Kleinfeld D, Correlations of neuronal and microvascular densities in cortex revealed by direct counting and colocalization of cell nuclei and microvessels, Journal of Neuroscience 29:14553-14570, 2009 Journal of Neuroscience 2009 Tsai.pdf
Shih AY, Friedman B, Drew PJ, Lyden PD, Kleinfeld D, Active dilation of penetrating arterioles compensates for deficient blood cell velocities to restore full perfusion of penumbral neocortex after stroke, Journal of Cerebral Blood Flow and Metabolism 29:738-51, 2009 J Cereb Blood Flow Metab 2009 Shih.pdf
Li L, Bender KJ, Drew PJ, Jadhav SP, Sylwestrak E, Feldman DE, Endocannabinoid signaling is required for development and plasticity of the whisker map in somatosensory cortex, Neuron 64:537-549, 2009 Neuron 2009 Li.pdf
Drew PJ, Feldman DE, Imaging of whisker deprivation-induced plasticity in the barrel cortex, Cerebral Cortex 19:331-348, 2009 Cerebral Cortex 2009 Drew.pdf
Wolfe J, Hill DN, Pahlavan S, Drew PJ, Kleinfeld D, Feldman DE. Texture Coding in the Rat Whisker System: Slip-Stick Versus Differential Resonance, PLoS Biol 6(8): e215, 2008 PLoS Biol 2008 Wolfe.pdf
Drew PJ, Feldman DE, Representation of moving wavefronts of whisker deflection in barrel cortex, Journal of Neurophysiology 98: 1566-1580, 2007 Journal of neurophysiology 2006 Drew.pdf
Drew PJ, Abbott LF, Extending the Range of Spike-Timing Dependent Synaptic Plasticity To Account for Behavioral Data, Proceedings of the National Academy of Sciences 103: 8876- 8881, 2006 Proceedings of the National Academy of Sciences 2006 Drew.pdf
Drew PJ, Abbott LF, Models and Properties of Power-Law Adaptation in Neuronal Systems, Journal of Neurophysiology 96:826-833, 2006 Journal of neurophysiology 2006 Drew.pdf
Fusi S, Drew PJ, Abbott LF, Cascade Models of Synaptically Stored Memories, Neuron 45:599- 611, 2005 Neuron 2005 Fusi.pdf
Drew PJ, Abbott LF, Model of Song Selectivity and Sequence Generation in Area HVc of the Songbird, Journal of Neurophysiology 89: 2697-2706, 2003 Journal of neurophysiology 2003 Drew.pdf
Drew P, Sayres R, Watanabe K, Shimojo S, Pupilary Response to Chromatic Flicker, Experimental Brain Research 136:256-62, 2001 Experimental Brain Research 2001 Drew.pdf